ChloroquineV1, France, Analysis, bibRecord, 000330

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Identifieur interne : 000330 ( France/Analysis ); précédent : 000329; suivant : 000331

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Auteurs : Patricia Melnyk [France] ; Virginie Leroux [France] ; Christian Sergheraert [France] ; Philippe Grellier [France]

Source :

Bioorganic and Medicinal Chemistry Letters [ 0960-894X ] ; 2006.

RBID : Hal:hal-00097328

Abstract

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.

Url:

https://hal.archives-ouvertes.fr/hal-00097328

Affiliations:

France

Links toward previous steps (curation, corpus...)

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to stream Main, to step Merge: 001E15
to stream Main, to step Curation: 001C10
to stream Main, to step Exploration: 001C10
to stream France, to step Extraction: 000330

Links to Exploration step

Hal:hal-00097328

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.</p>
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Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

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Abstract

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